Pharmacogenomics

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Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects.

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Pharmacogenomics is the study of how genes affect a person's response to drugs. This relatively new field combines pharmacology (the science of drugs) and genomics (the study of genes and their functions) to develop effective, safe medications and doses that will be tailored to a person's genetic makeup.

Ther 2003;8(1):71-83Pharmacogenomics Drug disposition, drug targets, and side effectsEvans, WE, and McLeod, HLNEJM 2003; 348:538-549Economic issues from molecule to marketplacePharmacogenomics eventually can lead to an overall decrease in the cost of health care because of decreases in:the number of adverse drug reactions,the number of failed drug trials,the time it takes to get a drug approved,the length of time patients are on medication,the number of medications patients must take to find an effective therapy, andthe effects of a disease on the body (through

To view the PDF illustration on this page, you will need Adobe Reader. What is pharmacogenomics? Pharmacogenomics uses information about a person's genetic makeup, or genome, to choose the drugs and drug doses that are likely to work best for that particular person.

PharmGKB is a comprehensive resource that curates knowledge about the impact of genetic variation on drug response for clinicians and researchers.

Getting you the right drug at the right dose at the right time is the goal of pharmacogenomics, which involves studying how your specific DNA sequence influences your response to medications. The drugs available today to treat cancer, heart disease and other conditions are powerful agents that work as intended in most patients.