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Creative Biolabs

Over the last 10 years, Creative Biolabs has becoming a leader of recombinant antibody (rAb) discovery and manufacturing, providing high quality service to customers in academia and industry fields all over the world.

Our cutting-edge hybridoma development and phage display platforms allow the production of the most comprehensive list of recombinant antibody products and extensive service portfolio at the most competitive price. Our products range from antibody / peptide libraries, Biosimilar cell lines, Chimeric antigen receptor (CAR) products, antibody-drug conjugates (ADCs) to engineered antibodies such as therapeutic antibodies, nanobodies, bispecific antibodies and intrabodies. We also provide professional custom antibody discovery and engineering services, featuring phage display library construction, antibody humanization, chimerization, engineered antibody production (Fab, scFc, tribody, bispecific antibody, nanobody, minibody, etc.), antibody labeling, hybridoma/stable cell line development, membrane protein production and cGMP-manufacturing which enable larger scale antibody production for development of animal-based assays and clinical trials.

http://www.creativebiolabs.net

Anti 5-FU Engineered Antibodies - Creative Biolabs

Creative Biolabs provides 5-FU engineered antibodies such as therapeutic antibodies, nanobodies, bispecific antibodies and intrabodies. We also provide antibody / peptide libraries, Biosimilar cell lines, Chimeric antigen receptor (CAR) products, antibody-drug conjugates (ADCs)

recombinant anti-aflatoxin B1 antibody/scfv/fab fragment

Anti-idiotypic (anti-aflatoxin B1) antibody is a recombinant protein produced in E. coli.
Recombinant Human Antibody Fab Fragment recognizes and binds to 2,3,4,7,8-PeCD, expressed in HEK 293 cells.
Recombinant Mouse Antibody Fab Fragment recognizes and binds to 2,3,4,7,8-PeCD, expressed in Chinese Hamster Ovary cells(CHO).
Recombinant Mouse Antibody scFv Fragment exhibits selective binding affinity to 2,3,4,7,8-PeCD, expressed in E. coli.
Recombinant Human Antibody scFv Fragment exhibits selective binding affinity to 2,3,4,7,8-PeCD, expressed in E. coli.
Recombinant Human Antibody recognises an antigen 2,3,4,7,8-PeCD, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-2,3,4,7,8-PeCD mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-2,3,4,7,8-PeCD mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Recombinant Mouse Antibody recognises an antigen 2,3,4,7,8-PeCD, expressed in Chinese Hamster Ovary cells(CHO).

recombinant anti-aflatoxin B1 antibody/scfv/fab fragment

recombinant A*02 antibody/scfv/fab fragment

Recombinant Human Antibody Fab Fragment shows strong binding capacity to Human A02, expressed in HEK 293 cells.
Recombinant Mouse Antibody Fab Fragment shows strong binding capacity to Human A
02, expressed in Chinese Hamster Ovary cells(CHO).
Recombinant Mouse Antibody scFv Fragment is closely related to binding with Human A02, expressed in E. coli.
Recombinant Human Antibody scFv Fragment is closely related to binding with Human A
02, expressed in E. coli.
Recombinant Human Antibody specifically reacts with Human A02, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-A02 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-A02 mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Recombinant Mouse Antibody specifically reacts with Human A
02, expressed in Chinese Hamster Ovary cells(CHO).

recombinant A*02 antibody/scfv/fab fragment

recombinant A. actinomycetecomitans antibody/scfv/fab fragment

Recombinant Human Antibody Fab Fragment shows strong binding capacity to A. actinomycetecomitans, expressed in HEK 293 cells.
Recombinant Mouse Antibody Fab Fragment shows strong binding capacity to A. actinomycetecomitans, expressed in Chinese Hamster Ovary cells(CHO).
Recombinant Mouse Antibody scFv Fragment is closely related to binding with A. actinomycetecomitans, expressed in E. coli.
Recombinant Human Antibody scFv Fragment is closely related to binding with A. actinomycetecomitans, expressed in E. coli.
Recombinant Human Antibody specifically reacts with A. actinomycetecomitans, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-A. actinomycetecomitans mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-A. actinomycetecomitans mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Recombinant Mouse Antibody specifically reacts with A. actinomycetecomitans, expressed in Chinese Hamster Ovary cells(CHO).

recombinant A. actinomycetecomitans antibody/scfv/fab fragment

recombinant A. awamori antibody/scfv/fab fragment

Anti-A. awamori Nanobody is a recombinant protein produced in E. coli.

recombinant A. awamori antibody/scfv/fab fragment

chicken mAb

Creative Biolabs offers the unique native chicken IgY antibody production service by our proprietary Native™ Antibody Discovery Platform. This platform can produce extraordinarily high specificity and affinity native antibodies to be used for biomedical research and antibody manufacturing. Learn more about chicken mAb.

de-immunization

The immunogenicity of biotherapeutic drugs is a significant problem during clinical applications. Many biotherapeutic drugs can develop unwanted immune responses in patients such as generation of anti-drug antibodies (ADAs), which results in treatment resistance and potentially life-threatening adverse effects. Although different techniques, including advanced technologies for the expression, purification and formulation of recombinant proteins, and the use of purely human or humanized proteins, have been developed to reduce the immunogenicity of biotherapeutic drugs, the problems remain to be completely eliminated. For instance, fully human antibodies, produced by phage display technology or transgenic mice, may still show degrees of immunogenicity.

Donkey Antibody Production

Scientists from Creative Biolabs are glad to introduce our Donkey Monoclonal Antibody Production Service.

Monoclonal Duck Antibody

Creative Biolabs is a leading service provider of monoclonal antibodies from various species. We are proud to introduce the duck monoclonal antibody production service to our clients all over the world. Duck antibodies have fewer possibilities of cross-recognition compared to mammalian antibodies because of natural structure differences.

Fab sequence

Creative Biolabs has established a solid high-throughput sequencing analysis platform for Fab library sequence analysis. There are several approaches to identify a possible binder from a Fab library after the screening. One approach is to isolate and sequence the positive clones from the library by Sanger sequencing. Another approach is to use next-generation sequencing method for identification. However, both methods have their drawbacks. Creative Biolabs has developed an advanced Magic™ Fab repertoire analysis method, which could facilitate the antibody development in a much more efficient and effective manner.

Ferret Antibody Production

Creative Biolabs is proud to offer the unique ferret monoclonal antibody production service through our advanced phage display technology. Our scientists are confident in providing one-stop service from immunization to antibody validation for the discovery of novel ferret antibodies with high specificity and affinity.

Ferret mAb

Creative Biolabs is able to discover naïve ferret monoclonal antibodies via our specific Native™ Antibody Discovery Platform.

Goat Antibody

Scientists from Creative Biolabs now provide customized antibody discovery services to isolate goat monoclonal antibodies with high specificity and affinity utilizing our proprietary technique platform, the Native™ Antibody Discovery Platform. Through this innovative platform, we can precisely pick desirable antibodies out of a large pool of native antibody candidates from antigen-specific B lymphocytes of the immunized goat.

Mutagenesis Services

Creatve Biolabs provide a series of mutagenesis services, which including Site-Directed Mutagenesis, Site-Saturation Mutagenesis as well as Random Substitutions.

differential scanning calorimetry

Differential scanning calorimetry (DSC) Serviceprovides biomoleculesanalysisservicein biopharmaceutical research

bispecific antibodies

Creative Biolabs is a specialized manufacturer of bispecific antibodies based on our advanced technology and years of experience.

therapeutic proteins

Therapeutic proteins are proteins that are engineered in the laboratory for pharmaceutical use, including noncovalent binders, proteins that affect covalent bonds which are almost all enzymes, and albumin. Therapeutic proteins are highly effective in vivo and have revolutionized treatment of diseases. Protein therapeutics permits an individualized treatment approach by supporting a specifically targeted therapeutic process by compensating the deficiency of an essential protein.

therapeutic antibodies

Creative Biolabs is a pioneer and undisputed global leader in the rapidly emerging market for therapeutic antibodies.

fab fragment

Creative Biolabs provides high quality Fab fragment antibodies. Key targets include ENO1, ITGA6, NOLC1, PERP

fab antibodies

Creative Biolabs provides high quality Fab fragment antibodies. Key targets include ENO1, ITGA6, NOLC1, PERP

stability assessment

Creative Biolabs has established a manufacturability assessment platform for a full cascade of therapeutic antibody drug discovery and development.

Manufacturability Assessment

To address these issues that lead to potential clinical failure, Creative Biolabs, as a leading service supplier in the biotechnology and biopharmaceutical fields, offer comprehensive and state-of-the-art manufacturability assessment platforms for your target candidate including the following scopes:

Chemical Stability/Post-translational Modifications
Asparagine Deamidation
Aspartate Isomerization
Oxidation
Free Cysteine Thiol Groups
N & O-Glycosylation
C-Terminal Lysine
Isoelectric Point

antibody repertoire

Creative Biolabs offers our clients an amazing high-throughput sequencing and protein expression platform to analyze antibody repertoires for full length natively paired antibodies. Our platform integrates next generation sequencing (NGS) and bioinformatics in parallel, which can sequence the diverse antibody repertoire at a rate of millions of clones per hour. It can be applied to enhance the understanding of immunology and to revolute the traditional drug discovery process to meet unmet clinical needs of infectious diseases, immune dysregulation and cancer.

in vivo phage display

Creative Biolabs offers a novel in vivo phage display method for clients all over the world. This method can be used for specifically and efficiently isolating the tissue-specific peptides bound to cell markers or cell-penetrating peptides (CPPs) for transporting chemotherapeutic agents. Our technical scientists are aimed to provide a reliable and robust selection system to meet our customer’s individual requirements.