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Updated by Dawn Hodgson on Jan 31, 2015
Dawn Hodgson Dawn Hodgson
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Food have leptin

What Does Leptin Do?
Leptin acts on receptors in the hypothalamus of the brain where it inhibits appetite by (1) counteracting the effects of neuropeptide Y (a potent feeding stimulant secreted by cells in the gut and in the hypothalamus); (2) counteracting the effects of anandamide (another potent feeding stimulant that binds to the same receptors as THC, the active ingredient of marijuana); and (3) promoting the synthesis of α-MSH, an appetite suppressant.
Leptin hormone for obesity and weight loss
Leptin hormone role of in obesity and food intake by Ray Sahelian, M.D. Leptin is a hormone secreted from adipocytes (fat cells) and functions to suppress appetite and increase energy expenditure. Leptin is a proinflammatory cytokine. In contrast, ghrelin, a protein known to trigger feeling of hunger, increases during periods of fasting and decreases after a meal.
Research Review: Leptin, ghrelin, weight loss - it's complicated
It's a grim statistic: Most people who go on a diet and lose weight end up regaining that weight within a year. Doesn't sound too promising. Why does this happen? Well, there are many reasons.