Nkosingiphile Mazibuko
The pigment production of bacterium has given mankind a better way and solutions of living, this concept covers a variety of bacteria including P aeruginosa, Streptomyces, Rhodococcus and etc. In our diversity most people have bad knowledge of microbes, well here are the emendations in the misconception of microbes, more specifically the pyocyanin of Pseudomonas aeruginosa. This is in regard to the toxicity and advantages of this pigment. I'd love to take you on a tour, Stay tuned to be stunned!!!
Pyocyanin is the Pigment produced by the Pseudomonas aeruginosa bacterium which is Pseudomonadaceae family under the Pseudononadota phylum. It was first isolated by Carle Gassard in 1882 then Straek and Wrede gave it chemical structure which was later corrected by Hillemann, 1938.
The beautiful blue color of pyocyanin pigment by the active culture of Pseudomonas aeruginosa in this nutritional agar plate is fascinating, it is the product of a donated electron by this pigment to molecular oxygen. It is amazing that Pyocyanin pigment has a chemical formula which is C13H10N2O but the phenotypical structure of P aeruginosa is gram-negative rod-shaped, asporogenous, and mono flagellated bacterium which is 0.5 - 1um wide.
Pyocyanin is an electrochemically active metabolite produced by the human pathogen Pseudomonas aeruginosa. It is a recognized virulence factor and is involved in a variety of significant biological activities including gene expression, maintaining fitness of bacterial cells and biofilm formation. It …
Pyocyanin is also a chemically interesting compound due to its unusual oxidation-reduction activity. Phenazine-1-carboxylic acid, the precursor to the bioactive phenazines, is synthesized from chorismic acid by enzymes encoded in a seven-gene cistron in Pseudomonas aeruginosa and in other Pseudomonads.
Biological control of plant diseases has been considered as a valuable alternative method to manage various plant diseases (Cook 1993). In plant pathology, the term bio-control applies to the use of microbial antagonists to suppress plant diseases as well as the use of host specific pathogens to control weed populations.
The statistics show that pyocyanin, a bacterial redox cycler, can replace the redox functions of complex III, acting as an electron shunt. Sub-μM pyocyanin was harmless, restored respiration and increased ATP production in fibroblasts from five patients harboring pathogenic mutations in TTC19, BCS1L or LYRM7, involved in assembly/stabilization of complex III. Pyocyanin normalized the mitochondrial membrane potential and mildly increased ROS production and biogenesis.
Hassani et al. [27] reported that the cytotoxicity of pyocyanin
produced by both strains P. aeruginosa PHA-1 and mutant S300-8,
against cancer cell line RD and normal cell line REF revealed that
low concentrations (7.81–31.25 μg ml-1) of had low activity on RD
cell line with inhibition rate ranged from 28 to 36% after 24 hrs of
incubation.
