Patong is Phuket's most popular beach and staying there is a matter of personal preference. It's not truly Thailand anymore, but there are plenty of restaurants, shops, marketplaces, bars, and go-go clubs in this large town. While the beach's busiest section is in the middle, the northernmost section is peaceful and gorgeous.
There are thousands of hotels to select from, but just a handful that can be considered luxurious, and only three of those are located directly on the beach. Patong is where you want to be if you're in town for the nightlife!