Oxycodone 30mg forsale wickr PLUGGING101

Oxycodone 30mg forsale

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Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917.3 It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.Label The first oxycodone containing product, Percodan, was approved by the FDA on April 12, 1950..

Synonyms

    Dihydrohydroxycodeinone
    Dihydroxycodeinone
    Oxicodona
    Oxycodone
    Oxycodonum

ID : IDS-NO-002
N02AA05
NSC-19043
PF-00345439
PTI-821
Oxycodone 30mg Indication

Oxycodone is indicated for the treatment of moderate to severe pain.Label There is also an extended release formulation indicated for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period

Associated Conditions

    Severe Pain
    Severe, Chronic Pain
    Acute, moderate Pain
    Acute, severe Pain
    Chronic, moderate Pain

Pharmacodynamics

Oxycodone acts directly on a number of tissues not related to its analgesic effect. These tissues include the respiratory centre in the brain stem, the cough centre in the medulla, muscles of the pupils, gastrointestinal tract, cardiovascular system, endocrine system, and immune system.Label Oxycodone's effect on the respiratory centre is dose dependant respiratory depression.Label The action on the cough centre is suppression of the cough reflex.Label Pupils become miopic or decrease in size, peristalsis of the gastrointestinal tract slows, and muscle tone in the colon may increase causing constipation.Label In the cardiovascular system histamine may be released leading to pruritis, red eyes, flushing, sweating, and decreased blood pressure.Label Endocrine effects may include increased prolactin, decreased cortisol, and decreased testosterone.Label It is not yet known if the effects of opioids on the immune system are clinically significant.

Mechanism of action

The full mechanism of oxycodone is not known.Label Under conditions of inflammation or hyperalgesia, opioid receptors in the heart, lungs, liver, gastrointestinal tract, and reproductive system are upregulated and transported to nerve terminals.3 Oxycodone and its active metabolites, noroxycodone, oxymorphone, and noroxymorphone are opioid agonists.1 These compounds passively diffuse across the blood brain barrier or may be actively transported across by an unknown mechanism.3 Oxycodone and its active metabolites can selectively bind to the mu opioid receptor, but also the kappa and delta opioid receptors in the central nervous system and periphery, and induce a G protein coupled receptor signalling pathway.3 Activation of mu opioid receptors inhibits N-type voltage operated calcium channels, inhibiting responses to pain.

Absorption

Oxycodone has an oral bioavailability of 60% to 87% that is unaffected by food.Label

The area under the curve is 135ng/mL*hr, maximum plasma concentration is 11.5ng/mL, and time to maximum concentration is 5.11hr in patients given a 10mg oral immediate release dose of oxycodone..

Metabolism

Oxycodone's hepatic metabolism is extensive and completed by 4 main reactions. CYP3A4 and 3A5 perform N-demethylation, CYP2D6 performs O-demethylation, unknown enzymes perform 6-keto-reduction, and unknown enzymes perform conjugation.1

Oxycodone is metabolized by CYP3A4 and CYP3A5 to noroxycodone and then by CYP2D6 to noroxymorphone.1 Noroxycodone and noroxymorphone are the primary circulating metabolites.Label Noroxycodone can also be 6-keto-reduced to alpha or beta noroxycodol.1

Oxycodone can be metabolized by CYP2D6 to oxymorphone and then by CYP3A4 to noroxymorphone.1 Oxymorphone can also be 6-keto-reduced to alpha or beta oxymorphol.1

Oxycodone can also be 6-keto-reduced to alpha and beta oxycodol.1

The active metabolites noroxycodone, oxymorphone, and noroxymorphone can all be conjugated before elimination.1

Hover over products below to view reaction partners

    Oxycodone
        oxymorphone
            noroxymorphone

alpha-oxymorphol + beta-oxymorphol

noroxycodone

noroxymorphone

alpha-noroxycodol + beta-noroxycodol

alpha-oxycodol + beta-oxycodol

Buy K 9 (Oxycodone Hydrochloride 30 mg)

Pill with imprint K 9 is Blue, Round and has been identified as Oxycodone Hydrochloride 30 mg. It is supplied by KVK Tech Inc..

Oxycodone is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics. FDA has not classified the drug for risk during pregnancy. Oxycodone 30 mg is classified as a Schedule 2 controlled substance under the Controlled Substance Act (CSA).