Creative Biostructure has established an advanced and leading platform to provide custom Mempro™ Virus-like Particles (VLPs) production services. This platform is based on our outstanding research team and our rich experience in VLPs production through these years, therefore, we assure you the first-class services and high-quality products.
https://www.creative-biostructure.com/mempro-virus-like-particles-vlps-production-324.htm
Measurements such as the entrapped aqueous volume per unit of phospholipid provides useful information to predict the entrapment efficiency of the population. The concentration of the phospholipids and the encapsulated contents are also crucial characteristics of liposomal systems and are required to calculate liposomal yields, costs, and optimise processes. Creative Biostructure employs various methods to characterize the liposome solution and the drug-loaded liposomes.
https://www.creative-biostructure.com/liposome-analysis-and-characterization-494.htm
Virus-like particles (VLPs) have developed to be a widely applied technology, faciliating biology and medicine research dramatically. Over the recent yrars, Creative Biostructure has focused on VLPs application and established an outstanding VLPs technology platform far beyond the field of vaccinology. We provide the best services for various VLPs applications with an expanding spectrum.
https://www.creative-biostructure.com/mempro-virus-like-particles-vlps-application-326.htm
During the past years, Creative Biostructure has developed an advanced MemPro™ Nanodisc Technology based on our outstanding MemPro™ Membrane Protein platform to solubilize and purify membrane proteins, promoting the development of membrane protein research greatly.
https://www.creative-biostructure.com/mempro-nanodisc-technology-376.htm
Nanodiscs are soluble nanoscale phospholipid bilayers, encircled and stabilized by membrane scaffold proteins (MSP). They have been proven to be powerful and promising tools to study membrane proteins. Compared with other strategies, such as liposomes, bicelles and detergent micelles, nanodiscs are more close to native environment where proteins remain monodisperse and active. Creative Biostructure offers a variety of approaches for nanodisc analysis, including surface plasmon resonance (SPR), Nuclear magnetic resonance (NMR) spectroscopy, electron paramagnetic resonance (EPR), native Polyacrylamide Gel Electrophoresis (PAGE), free flow electrophoresis (FFE) and Chromatography.
https://www.creative-biostructure.com/mempro-nanodiscs-analysis-services-475.htm
With years of experience in liposome production and development, Creative Biostructure has established a proprietary liposome platform to accommodate the increasing demand of novel liposome preparations. The application of liposomes to facilitate drug delivery has already had an incredible impact on many biochemical and biomedical areas. The scientists at Creative Biostructure have gleaned extensive experience in all types of lipid nanoparticle systems, and are dedicated to help the clients find better and cheaper solutions.
https://www.creative-biostructure.com/liposomes-in-drug-delivery-491.htm
Obtaining the accurate three-dimensional (3D) structure information of the target is helpful for the discovery and optimization of drug candidates, as well as the mechanism of action (MOA) studies. As a leading service provider in the field of structural biology, relying on the first-class structural biology technology platform that covers X-ray crystallography, cryo-electron microscopy (Cryo-EM) technology and protein NMR spectroscopy, Creative Biostructure provides a comprehensive solution of target structure determination, called MagHelix™ Gene-to-Protein and Gene-to-Structure, complemented with the most advanced biophysical methods to characterize target and target-ligand interaction. Our services support structure-guided lead discovery and optimization, as well as biological drug discovery, such as therapeutic antibody discovery.
https://drug-discovery.creative-biostructure.com/maghelix-gene-to-protein-and-gene-to-structure-p15
Obtaining the accurate three-dimensional (3D) structure information of the target is helpful for the discovery and optimization of drug candidates, as well as the mechanism of action (MOA) studies. As a leading service provider in the field of structural biology, relying on the first-class structural biology technology platform that covers X-ray crystallography, cryo-electron microscopy (Cryo-EM) technology and protein NMR spectroscopy, Creative Biostructure provides a comprehensive solution of target structure determination, called MagHelix™ Gene-to-Protein and Gene-to-Structure, complemented with the most advanced biophysical methods to characterize target and target-ligand interaction. Our services support structure-guided lead discovery and optimization, as well as biological drug discovery, such as therapeutic antibody discovery.
https://drug-discovery.creative-biostructure.com/structural-modeling-of-target-molecule-p16
Finding active compounds targeting a biological target is the first step in a drug discovery project, a process known as hit identification, and it can be challenging. In drug discovery programs, faster progress and lower attrition rates can be achieved by obtaining high-quality hits. There are many approaches to achieve this goal, from traditional high-throughput screening to virtual screening, fragment-based technology to high content screening. Creative Biostructure offers a range of customized solutions to help you succeed in the hit identification process. Our team will design a strategy for the project based on the nature of the project and the information available and the approaches we provide can be applied individually or in parallel.
https://drug-discovery.creative-biostructure.com/hit-identification-p20
After screening out the compounds showing potential activity against the target through the hit identification stage, it is necessary to carry out further characterization and optimization of these hit compounds. And this stage is termed as hit to lead. The goal of this stage is to identify the most promising hit series through limited structure-activity relationship (SAR) studies to enter the lead optimization and preclinical development stage. With a dedicated team of skilled scientists and technicians, Creative Biostructure provides MagHelix™ hit evaluation and lead identification (hit to lead) solutions to meet our clients’ needs and goals.
https://drug-discovery.creative-biostructure.com/hit-to-lead-p44
Once the most promising hit compounds have been identified as leads through the efforts of hit to lead, it will enter the stage of lead optimization and preclinical development of early drug development, which are the key processes for finalizing drug candidates entering clinical trials. Lead optimization aims to improve the properties of lead compounds including stability, potency, efficacy, exposure, safety, etc. Lead optimization involves a sophisticated iterative stage in which the bioactivity and drug activity of the lead series are extensively optimized through various screening filters, and development candidates are ultimately determined for preclinical development. Preclinical development, also known as IND-enabling studies, involves testing development candidates in various in vitro and in vivo assays to examine their safety pharmacology and toxicology profile.
https://drug-discovery.creative-biostructure.com/lead-optimization-and-preclinical-development-p28
Natural products are a source of chemical diversity and are an ideal starting point for most screening programs for pharmacologically active small molecules. Natural products can be extracted from tissues, cells, and secretions of microorganisms, animals, and plants. Crude extracts from any of these biological sources will contain a wide range of structurally diverse and novel compounds. Chemical diversity in nature is based on biological diversity. Pharmacognosy can offer the tools to identify, select, and process natural products destined for drug discovery. Usually, the natural product compound has some form of biological activity and that compound is known as the active principle - such a structure can evolve to become a discovery "lead".
https://drug-discovery.creative-biostructure.com/natural-product-identification-and-production-p40
Structure-based drug design (SBDD) is an approach of drug design based on molecular recognition, starting from the three-dimensional (3D) structure of ligands and targets. In this drug discovery strategy, the 3D structure of the target is crucial, which can be obtained by structural biology techniques or homology modeling, and then study the interaction mode of the ligand and the receptor via experimental or computational methods. On this basis, rational drug design is carried out.
https://drug-discovery.creative-biostructure.com/maghelix-structural-biology-and-sbdd-platform-p58
Computer-aided drug design (CADD) has penetrated into all aspects of drug discovery, and with the in-depth application of artificial intelligence and cloud computing, it is foreseeable that CADD will play a greater role in drug discovery projects in the future, improving efficiency and further reducing high costs of drug development. Creative Biostructure's CADD and virtual screening platform is a comprehensive platform for new drug discovery that integrates a variety of computer applications. It can be utilized for early preclinical research of small molecule drugs, peptides, antibodies, and therapeutic proteins.
https://drug-discovery.creative-biostructure.com/maghelix-cadd-platform-p59
Computer-aided drug design (CADD) has penetrated into all aspects of drug discovery, and with the in-depth application of artificial intelligence and cloud computing, it is foreseeable that CADD will play a greater role in drug discovery projects in the future, improving efficiency and further reducing high costs of drug development. Creative Biostructure's CADD and virtual screening platform is a comprehensive platform for new drug discovery that integrates a variety of computer applications. It can be utilized for early preclinical research of small molecule drugs, peptides, antibodies, and therapeutic proteins.
https://drug-discovery.creative-biostructure.com/maghelix-cadd-platform-p59
The process of looking for a new drug against a specific target for a certain disease commonly involves high-throughput screening (HTS), wherein large libraries of chemicals are tested for their ability to modulate the biological activity of the target. For instance, if the target is a novel GPCR, compounds will be screened for their ability to inhibit or stimulate the receptor; if the target is a protein kinase, the chemicals will be tested for their ability to inhibit the kinase. Creative Biostructure provides custom high-throughput screening services, and our biochemical/cell-based HTS technologies allow us to efficiently screen hits from a variety of compound libraries.
https://drug-discovery.creative-biostructure.com/high-throughput-screening-hts-p31
How to find or design a class of small molecule compounds that bind to the target and change its biological activity under the premise of known target structural information? Structure-based virtual screening (SBVS) is one of the significant means to solve such problems. By using computational methods and the three-dimensional (3D) structural information of the biological target, Creative Biostructure can help you study the underlying molecular interactions involved in protein-ligand binding, and screen out compounds for further optimization in a faster and more economical manner.
https://drug-discovery.creative-biostructure.com/structure-based-virtual-screening-p36
Ligand-based virtual screening (LBVS) is a good option for hit identification if the three-dimensional (3D) structure of the target is unknown or if it is challenging to perform virtual drug screening through structure-based methods. The LBVS strategy is based on the assumption that molecules with similar structures (e.g., chemical structures, pharmacophores, molecular fields) tend to have similar properties and functions. Methods of screening potential hits based on physical, chemical, and thermodynamic properties have proven to be reliable, and techniques such as substructure mining and fingerprint searches of LBVS are less time-consuming than the molecular docking technique of structure-based virtual screening (SBVS) strategy. Creative Biostructure provides LBVS solutions to support drug discovery projects. Generally, we first generate fingerprints with high dimension of features to describe the chemical characteristics of ligands and then apply similarity searching or machine learning approaches for screening in high-dimensional data.
https://drug-discovery.creative-biostructure.com/ligand-based-virtual-screening-p37
Fragment-based screening (FBS) is a widely utilized strategy for the discovery of lead compounds. Especially in the development of drugs against unconventional targets such as protein-protein interactions (PPIs), FBS has proven to be a viable alternative to high-throughput screening (HTS). Leveraging advanced fragment-based drug design (FBDD) platform, Creative Biostructure provides FBS solutions for customers with hit identification needs, which involve various biophysical methods to determine the exact binding fragments.
https://drug-discovery.creative-biostructure.com/fragment-based-screening-fbs-p41
Fragment-based screening (FBS) is a widely utilized strategy for the discovery of lead compounds. Especially in the development of drugs against unconventional targets such as protein-protein interactions (PPIs), FBS has proven to be a viable alternative to high-throughput screening (HTS). Leveraging advanced fragment-based drug design (FBDD) platform, Creative Biostructure provides FBS solutions for customers with hit identification needs, which involve various biophysical methods to determine the exact binding fragments.
https://drug-discovery.creative-biostructure.com/fragment-based-screening-fbs-p41
