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Creative BioMart Provides Experienced Outsourcing Contract Research for Epigenetic Drug Discovery.
The nucleosome is a complex composed of DNA and four pairs of histones (eight in total), including two groups of H2A and H2B dimers and two groups of H3 and H4 dimers. And the H1 is responsible for linking DNA between two nucleosomes.
https://www.creativebiomart.net/epigenetics/category/products/nucleosomes/
DNA methylation is the most basic epigenetic modification. In eukaryotes, the most common methylation modification is 5-methylcytosine (5mC), which is generated by attaching the methyl group to the fifth carbon of the pyrimidine ring of CpG island cytosine with the help of DNA methyltransferase (DNMT).
Creative BioMart provides you with high-quality, and high-purity small molecule modulators and inhibitors for studying the function of DNA methyltransferases (DNMTs) and histone methyltransferases (HMTs). We have a growing number of high-purity and specific inhibitors against these important enzymes.
Creative BioMart provides modulators and inhibitors for proteins and enzymes involved in DNA / histone demethylation. We can proudly guarantee that our small-molecule products are of high quality and high purity and are your ideal tool for studying epigenetic regulation mechanisms and epigenetic drug screening.
Creative BioMart now offers various types of extracts and lysates including, but not limited to, epigenetic gene overexpression lysates, nuclear extracts, cytoplasmic lysates, whole-cell lysates, and acid extracts. The extracts and lysates provided by us can serve as experimental controls for a variety of epigenetic exploring purposes, such as electrophoresis.
https://www.creativebiomart.net/epigenetics/category/products/extracts-lysates/
RNA methylation is one of the significant contents of epigenetics, in which m6A (N6-methyladenosine) is a relatively common modification, and this modification is dynamically reversible. It plays an important role in regulating gene expression, splicing, RNA editing, RNA stability, controlling mRNA degradation and mediating translation of circular RNAs (circRNAs).
The protein that recognizes and binds to the specific epigenetic modification is called “reader”. For example, acetylated lysine can be selectively recognized by a reader protein motif called bromodomain. At least 43 bromodomain-containing proteins have been identified in the human genome, most of which are important transcriptional regulators.
Creative BioMart offers a variety of modified histone peptide products and can also customize peptides according to your specific needs. These modified histone peptides can be used for enzyme activity studies of histone-modifying enzymes, small molecule inhibitor screening of specific enzymes, and other high-throughput applications.
n the field of epigenetics, changes in DNA methylation and histone post-translational modification patterns are the focus of research. Many proteins are involved in the process of DNA methylation and histone modification, some of which participate in binding modified DNA or histones, and others can catalyze or remove those specific chemical groups.
