Vickie Delgado

Oleoylethanolamine (OEA) or N-Oleoylethanolamine (OEA) is a molecule produced in the body, usually found in the intestines. Increasing evidence suggest that OEA may act as an endogenous neuroprotective factor and participate in the control of reward-related behaviors. Also, it has been described as a peripherally acting agent that reduces food intake and body weight gain.

The benefits of Oleoylethanolamine(OEA)

Benefits of Oleoylethanolamine powder is good to lose weight as appetite regulator and supports healthy cholesterol levels in adults.

Oleoylethanolamine as an Appetite suppressant

Suppressing appetite and thus reducing the intake of food is an effective way to controlling both energy balance and body weight. Since appetite suppression is a major controlling point for energy (food) intake, managing appetite is crucial in controlling healthy body weight, especially when combined with health conscious lifestyle choices that include attention to proper food intake, dietary supplementation, and exercise.

Oleoylethanolamine supplement helps regulate lipid metabolism, helps control hunger by sending appetite surpressant messages to the brain and has been shown to help lower both triglyceride and blood cholesterol levels.

Oleoylethanolamine for Body fat management

OEA is a safer peripheral mechanisms controlling appetite and energy expenditure, see more here.

The effects of OEA were first studied because it shares similarities with another chemical, a cannabinoid known as anandamide. Cannabinoids are related to the plant Cannabis, and anandamides present in the plant (and marijuana) can increase a person's desire to snack by triggering a feeding response. According to Wikipedia, Oleoylethanolamine is the monounsaturated analogue of the endocannabinoid anandamide. Although OEA has a chemical structure that is similar to anandamide, its effects on eating and weight management are different. Unlike anandamide, OEA acts independently of the cannabinoid pathway, regulating PPAR-α activity to stimulate lipolysis.

How does of Oleoylethanolamine(OEA) work?

In obese people, OEA can regulate the energy homeostasis and appetite mainly by activation of various receptors including proximal proliferator-activated receptor-α (PPAR-α), G-protein-coupled receptor 119 (GPR119) and transient receptor potential cation channel subfamily V (TRPV1). Indeed, OEA activates these receptors and delays meal initiation, reduces meal size, decreases intervals between meals and finally modulates body weight.

Moreover, some experimental studies shows that OEA also suppresses the expression of IL-6, interleukin-8 (IL-8), intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in TNF-α induced inflammation in human umbilical vein endothelial cells through the activation of inflammatory receptors. OEA also inhibited the nuclear factor kappa-B (NF-kB) pathway in the body. In YT et al's survey, OEA (50 µmol/L) inhibited the TNF-α induced VCAM-1 expression in HUVEC.

Oleoylethanolamine bodybuilding

Everybody seeks health through bodybuilding in the gym. OEA is increasingly popular to bodybuilders. In bodybuilding supplements fields, TTA (tetradecylthioacetic acid) is often synergistically used with Oleoylethanolamine (OEA), both of which also helps to burn fat and decrease appetite. TTA may also be very promising among anti-fat supplements, because it appears to burn fat independent of exercise; preliminary results suggest that the body simply appears to"remove" fat from itself instead of needing to have it burned off with physical activity.

Oleoylethanolamine reduces triglycerides and cholesterol, and, combined with a cannabinoid antagonist, blocks body weight gain and improves dyslipidaemia in animal models of obesity.

In addition, the systemic administration of Oleoylethanolamine has been found to modulate glucose homeostasis, as well as both insulin release and insulin signaling in both hepatocytes and adipocytes.

Some rereearch shows that Oleoylethanolamine supplement has positive effects on anxiety, and more trails and evidence are needed to support.