Best practice equipment design considerations span several areas (Table 9.1). Regulatory requirements ensure that processing objectives are consistently met. Economical requirements include lifecycle costs, such as capital, operation, validation, maintenance, cost of replacement (and revalidation if needed), staffing required to support ongoing operation (e.g., programming and calibration) and the scope of the supporting documentation and service from the vendor. Standard, easy-to-use, designs and components are less prone to failure with lower labour costs and maintenance. Components must conform to the standards of the country and operating facility (e.g., metric and voltage) to ensure compatibility and reduce the inventory of spare parts. Additional selection criteria include experience with components and vendors, and scalability. Long lead components, such as specially designed pumps, sensors and tanks, must be designed and ordered early.