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eukaryotic translation initiation factor 2-alpha kinase 2

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

eif2ak2 Protein, eukaryotic translation initiation factor 2-alpha kinase 2 - Creative BioMart

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

eif3m Protein, eukaryotic translation initiation factor 3, subunit M - Creative BioMart

This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required;for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the;encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of;mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome.

eif5 Protein, eukaryotic translation initiation factor 5 - Creative BioMart

Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of;bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting;functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si;et al., 1996 (PubMed 8663286)).

elovl6 Protein, ELOVL fatty acid elongase 6 - Creative BioMart

Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001 [PubMed 11567032]).[supplied by OMIM, Mar 2008]

entpd1 Protein, ectonucleoside triphosphate diphosphohydrolase 1 - Creative BioMart

CD39, nucleoside triphosphate diphosphohydrolase-1 (NTPDase 1), is an ectoenzyme that degrades ATP to AMP. It is a member of the ectonucleoside triphosphate dihydrolases (E-NTPDases), which are involved in regulation of extracellular nucleotide catabolism

ep300 Protein, E1A binding protein p300 - Creative BioMart

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

ephx1 Protein, epoxide hydrolase 1, microsomal (xenobiotic) - Creative BioMart

Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

esd Protein, esterase D - Creative BioMart

This gene encodes a serine hydrolase that belongs to the esterase D family. The encoded enzyme is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. This gene is used as a genetic marker for retinoblastoma and Wilsons disease.