The knowledge of structures of viruses at atomic resolution is beneficial and powerful in discovery and design of vaccine and anti-viral drug. Electron cryo-Microscopy (cryo-EM) is one of the three major methods to determine 3D structures of biological samples.
Cryo-electron microscopy (cryo-EM) can be used to visualize DNA or RNA structures based on our cryo-EM platform provided by Creative Biostructure. We develop a novel suite of tools to overcome the size and throughput limitations of cryo-EM, which can be applied to small molecules such as DNA or RNA.
https://www.creative-biostructure.com/Cryo-EM-for-DNA-Samples-589.htm
The ribosome is a translational machinery that serves as the site of protein synthesis. It is made from complexes of ribosomal RNAs (rRNAs) and proteins which are arranged into two distinct components of different sizes. The ribosome is one of the most complex of protein/RNA.
https://www.creative-biostructure.com/Cryo-EM-for-Ribosomes-597.htm
Cryo-Electron Microscopy (Cryo-EM) can present samples in a native state with imaging the sample’s intrinsic electron density, providing direct visualization of biological macromolecules, such as protein, nucleic acid, large complexes and so on. Conversely, X-ray crystallography must require crystallization of the specimen within non-physiological environments.
https://www.creative-biostructure.com/Cryo-EM-for-Subcellular-Organelles-598.htm
Conventional electron microscopy techniques have been crucial for studying the structure of biological specimens such as cells, tissues and macromolecules. But sample preparation of conventional electron microscopy requires complete dehydration which leads to material aggregation.
https://www.creative-biostructure.com/Cryo-EM-for-Biological-Tissues-599.htm
It is crucial that understanding the biological functions of macromolecules by characterizing the molecular structure. As the most effective method to obtain atomic models of proteins and nucleic acids in the 20th century, X-ray crystallography has been fundamental in the development of many scientific fields.
https://www.creative-biostructure.com/Cryo-EM-for-Bacteriophages-600.htm
Cryo-Electron Microscopy (Cryo-EM) techniques have been essential for understanding the structure of biological specimens such as cells, tissues and macromolecular complexes. Characterizing the molecular structure of macromolecules is crucial for getting an insight into understanding of the biochemical and cellular processes.
https://www.creative-biostructure.com/Cryo-EM-for-Filaments-606.htm
Cryo-electron microscopy (cryo-EM) is a form of transmission electron microscopy (TEM) where biological samples are studied at cryogenic temperatures. It is becoming a more and more important technique in the field of structural biology, as has been manifested by many once hard-to-determine macromolecular structures.
https://www.creative-biostructure.com/cryo-em-for-small-proteins-561.htm
