Mechanization in agriculture is a major advantage in all processes of farming. It reduces a lot of human efforts and time, besides increasing a hundred fold more efficiency. One of the essential and most used machinery these days are Combines. A Combine is nothing but a combination of machines such as Combine Harvester, Rotary Tiller, Plow, Tractor Trailer, Power Harrow, Ripper Machine, Water bowser, Leveler as well as Disc Harrow. According to many experienced agriculturists all over the world, John Deere Combines are the most coveted harvester in the current market. It carries out the well-known reputation of its manufacturers, John Deere & Company. But to reap maximum benefit from this high quality combines the John Deere combine settings are to be actualized perfectly. It can confirm optimum yield of quality grain. The major settings required in the John Deere Combines are listed below