Creative Bioarray

The genotoxicity testing of new chemical entities is an integral part of the drug development process and is a regulatory requirement prior to the approval of new drugs. By determing genotoxicity at an early stage in drug discovery rather than during regulatory assessment, the likelihood of late stage failures is reduced.

Drug-induced photosensitivity can be elicited by topical or systemic application of pharmaceuticals in combination with subsequent exposure to sunlight or artificial light.

Cells are structural and functional unit of our body which control and maintain the function of all unicellular and multicellular organisms. The process of cell proliferation and differentiation plays a key role from the time of embryogenesis to development of whole organism from single- or double- cell embryo and continues its critical role in maintenance of adult tissue homoeostasis by recycling the old cells with new cells. Besides, abnormal cell proliferation is also associated with human diseases like cancer. In sum, cell proliferation assays are very important in scrutinizing the rate of cell proliferation in both in vitro and in vivo conditions.

Creative Bioarray is offering cell immortalization service. With years of experience in cell immortalization, we have been able to successfully immortalize cells from human, mouse, bovine and dog, using different immortalizing agents or genes. Our custom immortalization service can significantly extend replicative capacity of your target cells, which saves your time and money over trying by yourself.

Primary cells normally have a limited life span and after having undergone a certain number of population doublings stop dividing, this is known as senescence. Re-establishing fresh cultures from explanted tissue is a tedious process. However, using immortalized cells can solve this problem. Immortalized cells have extended replicative capacity and offer the possibility of an inexhaustible supply of cells throughout your research project.

Creative Bioarray has more than ten years of experience in cell biology. And we have performed thousands of cell line testing services for clients in biopharma under cGMP and validated to current ICH guidelines. In addition, QC testing of cell lines, media, in-process material and final products has been demonstrated during the manufacture of pharmaceuticals and medical devices by our experts. Furthermore, experience allows us to advise our clients on the most appropriate process steps to study in order to satisfy regulators.

Creative Bioarray provides Cell Apoptosis Assays to all of our customers. The process of programmed cell death, or apoptosis, is generally characterized by distinct morphological characteristics and energy-dependent biochemical mechanisms. Apoptosis is considered a vital component of various processes including normal cell turnover, proper development and functioning of the immune system, hormone-dependent atrophy, embryonic development and chemical-induced cell death. Inappropriate apoptosis is a factor in many human conditions including neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of cancer. The ability to modulate the life or death of a cell is recognized for its immense therapeutic potential. Therefore, research continues to focus on the elucidation and analysis of the cell cycle machinery and signaling pathways that control cell cycle arrest and apoptosis.

Monocellular layers of tumors cultivated in vitro and mouse xenografts derived from those cells have been the standard toolkit for cancer biologists for decades. Unfortunately, continuous passage and culture of cells in vitro allows the least differentiated cells to thrive, resulting in distinct and irreversible losses of important biologic properties introduced by tumor resident cell populations, such as supporting non-tumor stroma, hematopoietic cells and other tumor microenvironmental factors. Based on this situation, mouse xenografts of human tumor cell lines have had poor predictive power in the translation of cancer therapeutics into clinical settings.

The cell cycle is the most fundamental and important process by which eukaryotic cells duplicate and divide. The cell cycle consists of two specific and distinct phases: interphase, consisting of G1 (Gap 1), S (synthesis), and G2 (Gap 2), and the mitotic phase; M (mitosis).

Creative Bioarray provides models and assays to help industries to develop better Dermatological formulations and products in preclinical stage.

Cosmetics are substances or products used to enhance or alter the appearance or fragrance of the body, which has become an essential element in our daily life. Creative Bioarray provides in vitro assays for serving personal care, and for helping industries to develop better cosmetic formulations and products.

Mucous membranes line the digestive, respiratory, and reproductive tracts and are the primary barrier between the external world and the interior of the body.

Creative Bioarray provides in vitro models and assays to help pharmaceutical industries to develop better oral, gingival, eye and airway mucosal care formulations and products in preclinical stage.

The knowledge of the mechanisms and drug response are essential for the development and assessment of new chemical entities for different kinds of cardiovascular diseases. Current drug therapies alleviate symptoms for only 50 to 70% of cardiovascular disease patients and often with unwanted side effects. Cardiotoxicity remains a major concern during drug development, with increased proarrhythmic potential being the main culprit.

Cell therapy is a therapy that relies on replacing diseased cells with healthy, functioning medicinal products, and is typically injected into a patient. This therapy have the potential to revolutionize care for a broad range of diseases, such as immune cells for cancer immunotherapy or stem cells for regenerative medicine.

Creative Bioarray provides prominent platform for Translation Oncology Research to find well-designed studies for our customers and help answer key questions about how cancer works in the body and what tests and treatments may work best.

With our abundant and various animal models, powerful molecular profiling and extensive-experienced research teams, Creative Bioarray is dedicated in designing the best clinical strategy for our customs on their Immuno-Oncology studying or drug discovery field.

Immuno-Oncology (I-O) is an emerging and evolving treatment modality that includes immunotherapies designed to utilize the body’s own immune system to fight diseases. The last 30 years of I-O research has progressed considerably with approvals for the use of various I-O therapies including vaccines, cytokines, tumor-directed monoclonal antibodies, and immune checkpoint inhibitors.

Oncology is a branch of medicine that deals with the prevention, diagnosis and treatment of cancer. Research contains mechanism study (including molecule mechanism), pathological research, surgical method, medical treatment therapy (chemotherapy, radiotherapy), management for an individual patient, new drug development, etc. Obviously, oncology is often managed through discussion on multi-disciplinary.

Creative Bioarray has performed many karyotyping (banded chromosome analysis) services for cell line authentication and some specific research. In providing karytoping information, we can promote the advancement of biology projects.

Breast Tumor Cells for you research are easily available at Creative Bioarray. We provide various animal and human cell lines that are invaluable for scientific, medical and pharmaceutical institutions.

Creative Bioarray provides cell proliferation assay service for our customer. We are capable of performing different cell proliferation assays based on several concepts, which are measuring rate of DNA replication, analysis of metabolic activity, cell surface antigen recognitions, detecting proliferation markers, ATP measurement, measures of membrane integrity and so on.

Cell immortalization service from Creative Bioarray comes with years of experience in cell immortalization, we have been able to successfully immortalize cells from human, mouse, bovine and dog, using different immortalizing agents or genes.

Creative Bioarray offers a wide range of cell line testing and assays from cell viability and proliferation to cellular phosphorylation assays.

Creative Bioarray offers a wide array of apoptosis assays for measuring multiple components on a choice of assay platforms, including Annexin V binding assays, Caspase activity assays, Mitochondrial membrane potential assays, DNA fragmentation and morphology and etc.

From the extensive platform of PDX models, Creative Bioarray has successfully derived a unique collection of disease relevant cell lines from various cancer types.

At Creative Bioarray, GTPγS binding assays can be implemented in several different formats, including SPA, FlashPlates and filtration formats.

Creative Bioarray’s cell-based reporter assays provide another popular and cost-effective HTS platform for GPCR screening.