Before taking Conjugated Estrogens (Premarin Vaginal Cream 14 gm), take all precautions as mentioned above and discuss about them with your doctor. Inform your doctor in advance if you have any of these conditions: lupus, porphyria, endometriosis, gallbladder disease, hypothyroidism, asthma, migraines, epilepsy, calcium deficiency, or if you have had a hysterectomy.