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Updated by Julian Lewis on May 12, 2018
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Julian Lewis Julian Lewis
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LIST of 5 HELPFUL METHODS of AMINO ACIDS

This list is talking all about the 5 useful methods of AMINO ACIDS, which help the students to gain knowledge about the AMINO ACIDS assignment. If you need help with your AMINO ACIDS assignment, visit our website: https://www.assignments4u.com/amino-acids-assignment-help/

1

METHOD#1

Amination of alpha-bromocarboxylic acids provides a straight forward
method for preparing alpha- amino carboxylic acids. The bromoacid are
conveniently prepared from carboxylic acids by reaction with Br2 + PCl3.

2

METHOD#2

By modifying the nitrogen as a phthalimide salt the propensity of amines to
undergo multiple substitutions is removed, and a single clean substitution
reaction of 1º- and many 2º-alkylhalides takes place.

3

METHOD#3

An elegant procedure known as the Strecker synthesis, assembles an alpha-amino acid fromammonia (the amine precursor), cyanide (the carboxyl precursor) and an aldehyde. Thisreaction is essentially an imino analog of cyanohydrin formation. The alpha-amino nitrileformed in this way can then be hydrolyzed to an amino acid by either acid or base catalysis.

4

METHOD# 4

Resolution The three synthetic procedures described above and many others thatcan be conceived, give racemic amino acid products. If pure L or D enantiomers aredesired, it is necessary to resolve these racemic mixtures.
A common method of resolving racemates is by diastereomeric salt formation with apure chiral acid or base.

5

METHOD # 5

Resolution The three synthetic procedures described above and many others thatcan be conceived, give racemic amino acid products. If pure L or D enantiomers aredesired, it is necessary to resolve these racemic mixtures.
A common method of resolving racemates is by diastereomeric salt formation with apure chiral acid or base.