Julian Lewis
This list is talking all about the 5 useful methods of AMINO ACIDS, which help the students to gain knowledge about the AMINO ACIDS assignment. If you need help with your AMINO ACIDS assignment, visit our website: https://www.assignments4u.com/amino-acids-assignment-help/
Amination of alpha-bromocarboxylic acids provides a straight forward
method for preparing alpha- amino carboxylic acids. The bromoacid are
conveniently prepared from carboxylic acids by reaction with Br2 + PCl3.
By modifying the nitrogen as a phthalimide salt the propensity of amines to
undergo multiple substitutions is removed, and a single clean substitution
reaction of 1º- and many 2º-alkylhalides takes place.
An elegant procedure known as the Strecker synthesis, assembles an alpha-amino acid fromammonia (the amine precursor), cyanide (the carboxyl precursor) and an aldehyde. Thisreaction is essentially an imino analog of cyanohydrin formation. The alpha-amino nitrileformed in this way can then be hydrolyzed to an amino acid by either acid or base catalysis.
Resolution The three synthetic procedures described above and many others thatcan be conceived, give racemic amino acid products. If pure L or D enantiomers aredesired, it is necessary to resolve these racemic mixtures.
A common method of resolving racemates is by diastereomeric salt formation with apure chiral acid or base.
Resolution The three synthetic procedures described above and many others thatcan be conceived, give racemic amino acid products. If pure L or D enantiomers aredesired, it is necessary to resolve these racemic mixtures.
A common method of resolving racemates is by diastereomeric salt formation with apure chiral acid or base.
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