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Updated by Randy Bauer on Mar 23, 2018
Headline for Therapeutic Health Benefits of Olea25® Hydroxytyrosol
Randy Bauer Randy Bauer
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Therapeutic Health Benefits of Olea25® Hydroxytyrosol

Olea25® granule powder contains a minimum of 25% Hydroxytyrosol. It is made from cultivated organic olive leaf. OLEA25® HYDROXYTYROSOL is intended for Medical and Health Care Practitioners, and may be private labeled to meet your brand.

  • Anti-Inflammatory
  • Antioxidant
  • Anti-Microbial
  • Heart Health
  • Neuroprotective
  • Cellular/Mitochondrial Support



Cardioprotective effects of the polyphenol hydroxytyrosol from olive oil

The Mediterranean diet includes olive oil as its primary source of fat. This diet is frequently associated to longevity and a lower incidence of chronic diseases thanks to its biological activities and health effects.
Apart from oleic acid, olive oil contains many bioactive components including polyphenols that have been reported to exert antioxidant and anti-inflammatory activities. Polyphenols may for the most part be responsible for the protective effects against cardiovascular diseases associated with olive oil. Hydroxytyrosol is one of the major phenolic compounds in olive oil and has demonstrated strong radical-scavenging properties. Several studies have been performed in order to look further into the effects of the polyphenol hydroxytyrosol in relation to cardiovascular events and illnesses in animal trials and in vitro. However, no clinical trials have focused on the specific action of hydroxytyrosol and cardiovascular diseases, although some are being undertaken to look at olive oil or olive leaf extract properties. In this review, the available literature on hydroxytyrosol effects as a cardioprotective agent is reported and discussed. Moreover, we also discuss the chemistry, nutritional aspects and bioavailability of hydroxytyrosol.

Olive Leaf Extract

~~ Along the bank of the river, on this side and that, will grow all kinds of trees used for food. Their leaves will not wither, and th...

Hydroxytyrosol Is the Major Anti-Inflammatory Compound in Aqueous Olive Extracts and Impairs Cytokine and Chemokine Prod

HT was identified as the main bioactive compound of OVW. The data provide a molecular basis for elucidating the effects of HT on inflammatory processes. The effects of HT on NO and chemokine production point to their impact on chronic inflammatory processes in endothelium or arthritis.Olea25HT-HealthCareDeck

Hydroxytyrosol: a new class of microbicide displaying broad anti-HIV-1 activity

To investigate the toxicity and activity against HIV of 5-hydroxytyrosol as a potential microbicide.The anti-HIV-1 activity of 5-hydroxytyrosol, a polyphenolic compound, was tested against wild-type HIV-1 and viral clones resistant to nucleoside reverse ...

Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomised co...

Dietary polyphenols have been demonstrated to favourably modify a number of cardiovascular risk markers such as blood pressure (BP), endothelial function and plasma lipids. We conducted a randomised,

OLEA25®HYDROXYTYROSOL- Health Benefits from Olive Leaf

OLEA25®HYDROXYTYROSOL is organic biotransformed technology at 25% from Olive Leaf. A Polyphenol of Mediterranean Diet with Benefits of Mitochondrial Biogenesis…
BHA Download HT reference/info letter

Olea25® hydroxytyrosol neuroprotect cytoprotect

Olea25® hydroxytyrosol is a polyphenol of olive leaf extract that supports health benefits of the Mediterranean Diet. Hydroxytyrosol is a potent antioxidant an…
BHA Download HT reference/info letter

Olea25® Hydroxytyrosol Heart Health Benefits

Olea25® Hydroxytyrosol is a polyphenol extracted from Olive Leaf by patented technology. Hydroxytyrosol is a major contributor to the health benefits of the Mediterranean Diet.

Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent an...

Hydroxytyrosol (HT), a major phenolic antioxidant found in olive oil, can afford protection from oxidative stress in several types of non-tumoral cells, including chondrocytes. Autophagy was recently identified as a protective process during osteoarthritis (OA) development and critical for survival of chondrocytes. Therefore we have investigated the possibility to modulate chondrocyte autophagy by HT treatment.
Bauer Health Action Nutraceutical Recommendations

Nutrition and healthy ageing: calorie restriction or polyphenol-rich "MediterrAsian" diet?

There are specific plant bioactives which predominantly occur in the Mediterranean (e.g., resveratrol from red wine, hydroxytyrosol, and oleuropein from olive oil) and in the Asian diets (e.g., isoflavones from soybean and epigallocatechin gallate from green tea). Interestingly, when compared to calorie restriction which has been repeatedly shown to increase healthspan, these polyphenols activate similar molecular targets such as Sirt1. We suggest that a so-called 'MediterrAsian' diet combining** sirtuin-activating foods (= sirtfoods)** of the Asian as well as Mediterranean diet may be a promising dietary strategy in preventing chronic diseases, thereby ensuring health and healthy ageing. Future (human) studies are needed which take the concept suggested here of the MediterrAsian diet into account.

How Intermittent Fasting, Caloric Restriction and Choice Polyphenols Effect Health and Aging - Bauer Health Action

Intermittent fasting, caloric restriction and choice polyphenols effect health and aging by activating Sirtuins. Hydroxytyrosol is a Sirt-1, Sirt food.

Protective effects of hydroxytyrosol on gentamicin induced nephrotoxicity in mice

Findings suggest that HT partly protected the kidneys from gentamicin induced nephrotoxicity and it is partly due to antioxidant effect of HT.

Health Benefits of Polyphenol Hydroxytyrosol

Health Benefits of Polyphenol Hydroxytyrosol from Olive Leaf Olea25® 25% Hydroxytyrosol, a polyphenol extracted from Olive Leaf. The Health Benefits of Hydroxyt

Olea25® Hydroxytyrosol Supports Mitochondrial Function

  Olea25®, a Food Grade Nutraceutical, is a plant-based Polyphenol containing 25% Hydroxytyrosol extracted from Olive Leaf with patent technology. Hydroxytyrosol supports mitochondrial function, and by way of anti-oxidant and anti-inflammatory actions promotes:
Heart Health
Metabolic Support
Joint Health

Introducing Axios Nutra Thrive by Nature - Bauer Health Action

Axios Nutra Thrive by Nature Nutraceutical Plant-Based Polyphenol, Full Spectrum Collagen Type I, II, III, V and X Supplements for Your Health and Healing.

Effects of hydroxytyrosol on cardiovascular and neuroprotective biomarkers in experimental diabetes mellitus

The aim of this study was to assess the influence of hydroxytyrosol (HT) on cardiovascular inflammation and neuroprotective
effect in streptozotocin-diabetic rats. Four groups of rats (N=10 per group) were studied for 2 months: nondiabetic rats (NDR),
diabetic rats treated with saline (DR) and DR treated with HT (1, and 5 mg/kg/day p.o.). At the end of follow-up an experimental
model of hypoxia-reoxygenation in brain slices was tested. Vascular variables: DR had higher platelet aggregation values,
higher thromboxane B2, plasma lipid peroxidation, 3-nitrotyrosine, oxidized LDL (oxLDL), myeloperoxidase, vascular cell adhesion molecule 1 (VCAM-1)
and interleukin-1β (IL-1β) concentrations, and lower aortic 6-keto-prostaglandin F1α and nitric oxide production than NDR. Aortic wall area and smooth muscle cell count were also higher in DR than in NDR. Brain
variables: the DR group showed increased cell death, oxidative and nitrosative stress and an increase in brain inflammatory
mediators. HT significantly reduced both oxidative and nitrosative stress, oxLDL concentration (35% and 40% of reduction respect
untreated animals for 1 or 5 mg/kg/day respectively), VCAM-1 (63% and 50%), platelet aggregation (22% and 40%) and thromboxane
B2 production (22% and 25%). Morphometric values in the aortic wall were reduced to values near those in NDR. Respect the brain
variables the result obtained were the following: HT significantly reduced oxidative lipid peroxidation (38% and 52 of reduction
respect untreated animals for 1 or 5 mg/kg/day respectively) and nitrosative stress (47% and 50%) and peroxynitrite concentration
(43% and 60%) and brain inflammatory mediators (19–30% prostaglandin E2 and 16–50% interleukin 1β concentration). Cell death was reduced by 26% and 38% after the administration of 1 or 5 mg/kg/day.

Impact of Youth Sports Injury on Joint Arthritis- Natural Alternatives to Reduce Osteoarthritis Progression

Youth sports injuries of ACL and Mensicus impacts onset of osteoarthritis in adulthood. Joint health support with Olea25® Hydroxytyrosol and TendoGuard™.

Olea25® Hydroxytyrosol – Axios Nutra

Olea25® Hydroxytyrosol is a natural polyphenol extracted 25% Hydroxytyrosol from Olive Leaf. Olea25 is a strong anti-oxidant and anti-inflammatory benefitting heart, joint, nervous system, and cellular health. Yields 25mg Hydroxytyrosol per 100mg Capsule.

Modulation of the Senescence-Associated Inflammatory Phenotype in Human Fibroblasts by Olive Phenols

Senescent cells display an increase in the secretion of growth factors, inflammatory cytokines and proteolytic enzymes, termed the “senescence-associated-secretory-phenotype” (SASP), playing a major role in many age-related diseases. The phenolic compounds present in extra-virgin olive oil are inhibitors of oxidative damage and have been reported to play a protective role in inflammation-related diseases. Particularly, hydroxytyrosol and oleuropein are the most abundant and more extensively studied. Pre-senescent human lung (MRC5) and neonatal human dermal (NHDF) fibroblasts were used as cellular model to evaluate the effect of chronic (4–6 weeks) treatment with 1 μM hydroxytyrosol (HT) or 10 μM oleuropein aglycone (OLE) on senescence/inflammation markers. Both phenols were effective in reducing β-galactosidase-positive cell number and p16 protein expression. In addition, senescence/inflammation markers such as IL-6 and metalloprotease secretion, and Ciclooxigenase type 2 (COX-2) and α-smooth-actin levels were reduced by phenol treatments. In NHDF, COX-2 expression, Nuclear Factor κ-light-chain-enhancer of activated B cells (NFκB) protein level and nuclear localization were augmented with culture senescence and decreased by OLE and HT treatment. Furthermore, the inflammatory effect of Tumor Necrosis Factor α (TNFα) exposure was almost completely abolished in OLE- and HT-pre-treated NHDF. Thus, the modulation of the senescence-associated inflammatory phenotype might be an important mechanism underlying the beneficial effects of olive oil phenols.

Return to Play with Degenerative Joint Disease

Football is one of the most popular sports. Overall, it is associated with a high incidence of injuries. Most injuries affect the lower limbs, and thereby particularly the knee joint is in focus....