variable domain

Creative Biolabs has established a platform to predict a series of post-translational modifications of therapeutic proteins, such as antibodies, blood factors, hormones and interferons. Glycosylation is one of the common post-translational modifications. The carbohydrate attaches the amino acid residues at the nitrogen atom of Asparagine for N-Glycosylation and the oxygen atom of Serine and Threonine for O-linked glycosylation. When immunoglobulin V-genes contain Asparagine resides in the CDRs, an N-glycosylation motif may be formed during selection, of which approximately 20% antibodies are glycosylated in the variable regions.

Creative Biolabs is a leading sequencing company. gladly to show a series of unrivalled de novo antibody sequencing services for research, diagnostic and therapeutic industries.

Fab fragments differ from scFv's as they contain both variable domains and constant regions, thus their construction and ultimate expression is somewhat more complex. Creative Biolabs is experts with many years of experience in antibody production. The same heavy and light variable chains used for scFv construction can be used in the construction of Fab. For more about fc region of acntibody.

Creative Biolabs provides a full range of services based on our matured hybridoma platform. Our featured services involve the custom monoclonal antibody production, from gene expression or peptide synthesis to antibody purification and labeling. For more about monoclonal antibody technology.

Creative Biolabs is pleased to offer customized library construction services under a variety of phage display systems. Our scientists have extensive experience in library construction and are professional in generating different types of phage display libraries, including scaffold libraries, peptide libraries, antibody libraries, cDNA libraries and others. For more about display construction.

As a well-recognized expert at phage display technology, Creative Biolabs offers our worldwide clients the best phage display library screening services through our excellent biopanning strategies and state-of-the-art equipment. Our scientists are pleased to tailor the most appropriate strategies to screen the interested libraries of our customers.

Creative Biolabs provides high quality Fab fragment antibodies. Key targets include ENO1, ITGA6, NOLC1, PERP

itc isothermal titration calorimetry: Creative Biolabs offers isothermal titration calorimetry (ITC) services, which provide incomparable sensitivity with high quality binding data for biomolecular interactions of interest. Our ITC services have been used extensively in studying macromolecule interactions with studies looking at antibody-antigen, protein-protein, protein-ligand, DNA-ligand and RNA-macromolecule studies.

itc calorimetry: Creative Biolabs offers isothermal titration calorimetry (ITC) services, which provide incomparable sensitivity with high quality binding data for biomolecular interactions of interest. Our ITC services have been used extensively in studying macromolecule interactions with studies looking at antibody-antigen, protein-protein, protein-ligand, DNA-ligand and RNA-macromolecule studies.

Creative Biolabs offers isothermal titration calorimetry (ITC) services, which provide incomparable sensitivity with high quality binding data for biomolecular interactions of interest. Our ITC services have been used extensively in studying macromolecule interactions with studies looking at antibody-antigen, protein-protein, protein-ligand, DNA-ligand and RNA-macromolecule studies.

isothermal calorimetry: Creative Biolabs offers isothermal titration calorimetry (ITC) services, which provide incomparable sensitivity with high quality binding data for biomolecular interactions of interest. Our ITC services have been used extensively in studying macromolecule interactions with studies looking at antibody-antigen, protein-protein, protein-ligand, DNA-ligand and RNA-macromolecule studies.

dual polarization interferometry: Creative Biolabs offers dual-polarization interferometry (DPI) services, which provide exquisite sensitivity to give previously unavailable insights into the structural changes taking place in molecular systems as they function and interact. DPI resolves protein structure to subatomic dimensions in real time and is typically used to characterize biochemical interactions by quantifying any conformational change at the same time as measuring reaction rates, affinities and thermodynamics.

dual polarisation interferometry: Creative Biolabs offers dual-polarization interferometry (DPI) services, which provide exquisite sensitivity to give previously unavailable insights into the structural changes taking place in molecular systems as they function and interact. DPI resolves protein structure to subatomic dimensions in real time and is typically used to characterize biochemical interactions by quantifying any conformational change at the same time as measuring reaction rates, affinities and thermodynamics.

dsc service: Creative Biolabs is a recognized service provider in differential scanning calorimetry (DSC). DSC is a powerful analytical tool for characterizing the stability of proteins and other biomolecules directly in its native form with the aid of suitable thermodynamic models.

dsc differential scanning calorimetry: Creative Biolabs is a recognized service provider in differential scanning calorimetry (DSC). DSC is a powerful analytical tool for characterizing the stability of proteins and other biomolecules directly in its native form with the aid of suitable thermodynamic models.