Ashish Khera
Everyone gets bruised, scratched or wounded at some point in their lives. But all wounds eventually heal. The harmonious process of regenerating blood vessels, damaged tissues, and eventually skin is an almost ‘magical’ process’. The magic of biology.
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Under normal conditions, wound healing is a dynamic process involving four phases - Coagulation, Inflammation, Tissue Formation and Tissue Remodeling, that overlap in time.
A large number of cellular factors regulate these processes. Among them, Vascular endothelial growth factor (VEGF) has been identified as one of the most potent and predominant, potentially playing a pivotal role in each phase of wound healing, particularly in the promotion of angiogenesis.
Video Credits: Scientific Animations
Angiogenesis is the process by which new blood vessels grow and is a critical component of Wound Healing providing nutrients to newly formed tissues.
Most types of injuries damage blood vessels. The resulting coagulation is a rapid fire response to initiate hemostasis and protect against excessive blood loss.
Video Credits: Scientific Animations
With the aggregation and degranulation of platelets within the forming fibrin clot, a number of mediators and cytokines are released including vascular endothelial growth factor (VEGF) that initiate the tissue repair process.
*VEGF *has multiple functions. It acts as a vascular permeability factor influencing the extubation of plasma proteins to create a temporary support structure into which leukocytes, fibroblasts, endothelial cells and epithelial cells subsequently migrate.
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Scientific Animations is a full-service Medical Animation and Integrated e-Learning Solutions company founded in 2004 by veteran Indian-American entrepreneurs Girish Khera and Ashish Khera. The com...
