Candy Swift
Asparagine deamidation could cause charge heterogeneity and hence affect the antibody function if it locates in a binding surface such as CDRs. Deamidated residues are likely susceptible to Aspartate isomerization or result in protein fragmentation, aggregation and immunogenicity.
This is Candy Swift from Creative Biolabs, a biotech supplier that focuses on the research and development of antibody and antibody services. Lear more at http://www.creative-biolabs.com.
