candyjkswift
Creative Biolabs has developed the Fully Human Antibody Technology™ (FHAT) to produce fully human monoclonal antibodies in mice. Learn more about anti human antibodies.
Creative Biolabs has established the Hi-AffiTM platform to develop high affinity human monoclonal antibodies derived from non-human primates (NHPs). Learn more about humanized mouse monoclonal antibody.
Recombinant Anti-HER2 × Anti-CD3 Bi-specific T-cell engagers (Triomab, Ertumaxomab) is available from creative biolabs.
Creative Biolabs is glad to show a series of unique de novo antibody sequencing services for research, diagnostic, and therapeutic industries. To overcome the current drawbacks of sequencing based on traditional methods, Creative Biolabs has developed the proprietary Database Assisted Shotgun Sequencing (DASS) technology, which based on our next generation antibody sequencing platform. Our services consist of variable region, variable plus leader region, as well as full-length heavy- and light-chain antibody sequencing for all species, isotypes, and allotypes. Purified monoclonal antibodies in multivalent forms can be sequenced with 100% coverage of the desired regions as well as excellent accuracy. Numerous successful cases from Creative Biolabs have confirmed our qualification to provide antibody sequencing with 100% accuracy and satisfaction guarantee to meet our customers’ needs.
Creative Biolabs has established a platform to predict a series of post-translational modifications of therapeutic proteins, such as antibodies, blood factors, hormones and interferons. Glycosylation is one of the common post-translational modifications. The carbohydrate attaches the amino acid residues at the nitrogen atom of Asparagine for N-Glycosylation and the oxygen atom of Serine and Threonine for O-linked glycosylation. When immunoglobulin V-genes contain Asparagine resides in the CDRs, an N-glycosylation motif may be formed during selection, of which approximately 20% antibodies are glycosylated in the variable regions.
Creative Biolabs is glad to show a series of unique de novo antibody sequencing services for research, diagnostic, and therapeutic industries. To overcome the current drawbacks of sequencing based on traditional methods, Creative Biolabs has developed the proprietary Database Assisted Shotgun Sequencing (DASS) technology, which based on our next generation antibody sequencing platform. Our services consist of variable region, variable plus leader region, as well as full-length heavy- and light-chain antibody sequencing for all species, isotypes, and allotypes. Purified monoclonal antibodies in multivalent forms can be sequenced with 100% coverage of the desired regions as well as excellent accuracy. Numerous successful cases from Creative Biolabs have confirmed our qualification to provide antibody sequencing with 100% accuracy and satisfaction guarantee to meet our customers’ needs.
Creative Biolabs is pleased to offer customized library construction services under a variety of phage display systems. Our scientists have extensive experience in library construction and are professional in generating different types of phage display libraries, including scaffold libraries, peptide libraries, antibody libraries, cDNA libraries and others.
Creative Biolabs has established a solid platform for scFv and Fab construction. There are three routes to have a scFv or Fab targets a specific antigen. The first approach is to generate a mouse hybridoma clone, then convert full IgG (or IgM) into a scFv or Fab; the second approach is to create an immunized phage display scFv or Fab mouse library, then use the antigen to screen the library; the third method is to use the antigen to screen a premade scFv or Fab antibody phage display library (usually a human one) to get scFv or Fab clones directly. We are also able to convert chicken IgY into scFv or Fab fragments.
Creative Biolabs has years of experience in the field of antibody development and phage display technology. Our scientists are confident in generating antibody libraries with a diversity of 108-10, which can meet the needs of the vast majority of research. Meanwhile, we also have extensive experience in designing the most appropriate biopanning strategy to select reliable antibodies with high specificity and affinity. In addition to the regular antibody libraries of experimental animals, our scientists are also able to generate a series of unique antibody libraries from other species, such as human, guinea pig, shark and alligator. As one of the well-recognized industry leaders, Creative Biolabs is committed to offering the most comprehensive antibody production services and providing the best service with high efficiency and quality.
Creative Biolabs offers dual-polarization interferometry (DPI) services, which provide exquisite sensitivity to give previously unavailable insights into the structural changes taking place in molecular systems as they function and interact. DPI resolves protein structure to subatomic dimensions in real time and is typically used to characterize biochemical interactions by quantifying any con
Manufacturability assessment offers the opportunity to evaluate the technical viability of a drug candidate at the industrial scale and functions as a bridge between discovery and process development stage. Creative Biolabs is able to evaluate key manufacturability parameters, including productivity and process yield, chemical stability, PTMs, physical stability, aggregation, electrostatic properties, and formulability (including viscosity, solubility at high concentration, and accelerated stability) through our CreDA™ platform, and the comprehensive assessment results can effectively guide the customer to select the most appropriate candidate for process development.
With our versatile GlycoOpitimize™ platform, Creative Biolabs provide antibody glycoengineering service for our clients all over the world. We are able to produce glyco-optimized antibodies in a range of cell lines both for research quantities and in large scale. Other than antibody production, we also provide cell line development and downstream biopharmaceutical process development service. Creative Biolabs offers glycan analysis service for research, manufacturing & clinical development based on our optimally equipped laboratories as well.
Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin.
DutaMab, a novel format of BsAbs, is formed by linking two independent paratopes in a single immunoglubin chain. Taking advantage of the diversity of natural CDRs, two paratopes targetting their own antigen are generated with great stability. Thus, DutaMab is able to bind to two targets with high affinity simultaneously. Meanwhile, its lower-than-picomolar affinities, outstanding chemical stability and good manufacturing properties also make it one of the leading candidates in therapeutic development. Over the past decade, Creative Biolabs has established an excellent technology platform for antibody engineering which can meet the increasing needs from our customers.
Creative Biolabs is a leader biotech company in antibody field with cutting-edge techniques in pharmaceutical research and diagnostic trials. If you need more service or further information, please do not hesitate to contact us.
DVD-IgG is one type of bispecific antibody format, which is generated from two parental mAbs by placing two variable domains from one parental antibody onto the heavy chain and the light chain of another parental antibody, instead of one variable domain. The variable domain pairs can be derived from whole human, mouse or rat mAbs with phage/yeast display libraries. And the short peptides derived from the N-termini of CH1 or CL link the outer variable domain (VD1) and the inner variable domain (VD2) together. The DVD-IgG retains the antigen-binding specificity, affinity, and biologic activities from its both parental antibodies, therefore, all of its four variable domains are functional. Many different DVD-IgGs have been designed and manufactured for treating complex diseases with multiple mediators contributing to overall disease pathogenesis.
Creative Biolabs provides the high efficiency antibody production services in all kinds of expression systems. With our top technical scientists and unique optimized protocols, we can rapidly evaluate and identify the optimal expression condition for a candidate antibody to meet our customer’s special requirements.
Creative Biolabs has established a solid platform for scFv and Fab construction. There are three routes to have a scFv or Fab targets a specific antigen. The first approach is to generate a mouse hybridoma clone, then convert full IgG (or IgM) into a scFv or Fab; the second approach is to create an immunized phage display scFv or Fab mouse library, then use the antigen to screen the library; the third method is to use the antigen to screen a premade scFv or Fab antibody phage display library (usually a human one) to get scFv or Fab clones directly. We are also able to convert chicken IgY into scFv or Fab fragments.
Creative Biolabs provides a full range of services in custom polyclonal and monoclonal antibody production from gene expression or peptide synthesis to antibody purification and labeling. We have the capacity of producing antibodies in either research quantities or in large scale for diagnostic industry. We do epitope prediction, peptide synthesize, protein expression, polyclonal or monoclonal antibody production as well as antibody purification from cell culture, ascites fluid or whole serum. We also prepare mono-specific polyclonal antibodies by ligand affinity chromatography. Importantly, we can produce monoclonal antibodies within 70 days. Creative BioLabs also has the expertise in handling antigen insufficiency and targeting very impure antigens.
Protein purification is a series of processes intended to isolate a single type of protein from a complex mixture, which is vital for the characterization of the function, structure and interactions of the protein of interest. As an industry leader in recombinant antibody and protein production, Creative Biolabs is pleased to launch the best protein purification service. With years of experience in purification of thousands of proteins, Creative Biolabs has the necessary know-how to deliver the best possible results.
No matter the protein is produced at Creative Biolabs or provided by the client as cell pellets, bacterial paste or conditioned medium, Creative Biolabs can propose a solution to quickly and cost-effectively purify your proteins to your specifications.
Creative Biolabs is one of the well-recognized experts who is professional in applying advanced phage display technologies for a broad range of project objectives. With years of experience, our scientists can offer high-quality phage display library construction and custom phage display library screening services to meet our clients’ demands precisely. Particularly, our services also involve specific antibody discovery (e.g. PTM-specific antibody, anti-idiotype antibody, and agonistic antibody) and peptidome discovery.
Through modern recombination techniques, the genes of a set of specific glycosyltransferases and/or glycosidases can be systematically knockoutockin or regulated to produce glycoengineered antibodies with more humanized and homogeneous glycosylation, better pharmacokinetics and enhanced pharmacological efficacy. Our antibody production systems include mammalian cell lines (CHO, NS0 and SP2/0), yeasts (Pichia pastoris, Saccharomyces cerevisiae and Saccharomyces cerevisiae), baculovirus-infected insect cells, avian cells (Duck embryonic stem cells), plant cells (lemna minor, Physcomitrella patens and tobacco) and so on. Our scientists are fully confident to provide efficient and economically feasible antibody glycoengineering solutions.
Creative Biolabs offers our expertise in Zybody design and construction for your research and development projects in both academic and clinical fields. We are confident to deliver you the best procedure to meet your individual requirements.
Zybody is engineered by fusing modular recognition domains (MRDs) to N- and C-termini of both the heavy and the light chains of a full-length monoclonal antibody (mAb). It is a multi-specific, multi-valent antibody format that enhances the activity of conventional mAb without compromising their desirable drug-like properties. The MRDs include small polypeptides sequences (< 60 amino acids), domain-based structures selected for target specificity, such as knottins or Protein A Scaffolds, unstructured (linear) or disulfide-constrained peptides. Zybodies possess up to four distinct specificities, depending on the number of MRDs fused to the mAb scaffold, while retaining the original functionality and specificity of the scaffold antibody.
Recombinant monoclonal antibody to RhD. Atorolimumab is an immunosuppressive drug directed against the Rhesus factor.
